Day 2 Notes

Population Genomics

Population Genomics: The study of variation in a large group of individuals

SNPs

  • DNA varies roughly 1 in 1000 bases
  • These changes are know as SNPs
  • Different versions of a gene are called alleles
  • We all have 2 alleles for each gene: this set of alleles is known as GENOTYPE

SNPs Influence Traits

  • Depending on the gene in which it resides a SNP may increase or decrease the chance of a trait (phenotype) occuring

  • Some traits are influenced by many genes which means lots of SNPs may be linked to them
  • Height has over 22000 related SNPs!!

But what about mutation???

  • Both Are Changes but SNps are common and occur in 99.9% of the population​

-SNPS that are present in a population with a particular trait but not in a population without the trait are said to be “associated” with that trait

  • This research is known as GWAS

  • Genome Wide Association Study

Finding SNPs can help us:

  • Understand why people differ

  • Predict whether someone will have a trait